A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice
Abd-Elrahman KS, Colson TL, Sarasija S, Ferguson SSG. A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice. Biomed Pharmacother. 2024 Mar 8;173:116388. doi: 10.1016/j.biopha.2024.116388. Epub ahead of print. PMID: 38460371.
Sexual dimorphism of G protein-coupled receptor signaling in the brain
Aljoudi S, Hamdan H, Abd-Elrahman KS. Sexual dimorphism of G protein-coupled receptor signaling in the brain. Neural Regen Res. 2024 Aug 1;19(8):1635-1636. doi: 10.4103/1673-5374.389637. Epub 2023 Dec 11. PMID: 38103217; PMCID: PMC10960278
Targeting mGluR group III for the treatment of neurodegenerative diseases
Rabeh N, Hajjar B, Maraka JO, Sammanasunathan AF, Khan M, Alkhaaldi SMI, Mansour S, Almheiri RT, Hamdan H, Abd-Elrahman KS. Targeting mGluR group III for the treatment of neurodegenerative diseases. Biomed Pharmacother. 2023 Dec;168:115733. doi: 10.1016/j.biopha.2023.115733. Epub 2023 Oct 18. PMID: 37862967.
The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer’s Disease
Abd-Elrahman KS, Sarasija S, Ferguson SSG. The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer’s Disease. Curr Neuropharmacol. 2023;21(2):273-283. doi: 10.2174/1570159X19666210916102638. PMID: 34530715; PMCID: PMC10190143.
A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice
Abd-Elrahman, K. S., Sarasija, S., Colson, T.-L. L., & Ferguson, S. S. G. (2022). A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice. British Journal of Pharmacology, 179(8), 1769–1783. https://doi.org/10.1111/bph.15750
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer’s Disease
Abd-Elrahman KS, Ferguson SSG. Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer’s Disease. Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:235-254. doi: 10.1146/annurev-pharmtox-021821-091747. Epub 2021 Sep 13. PMID: 34516293.
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner
Khaled S. Abd-Elrahman et al. ,Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner.Sci. Signal.13,eabd2494(2020).DOI:10.1126/scisignal.abd2494
mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease
Abd-Elrahman KS, Hamilton A, Hutchinson SR, Liu F, Russell RC, Ferguson SSG. mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease. Sci Signal. 2017 Dec 19;10(510):eaan6387. doi: 10.1126/scisignal.aan6387. PMID: 29259100.
