Positive allosteric modulation of M1 mAChRs with VU0486846 reverses cognitive deficits in male APPswe/PSEN1ΔE9 alzheimer’s mice.
Ibrahim KS, Colson TL, Ferguson SSG, Abd-Elrahman KS. Positive allosteric modulation of M1 mAChRs with VU0486846 reverses cognitive deficits in male APPswe/PSEN1ΔE9 alzheimer’s mice. Neuropharmacology. 2025 Dec 1;280:110654. doi: 10.1016/j.neuropharm.2025.110654. Epub 2025 Aug 23. PMID: 40854473.
Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production.
Kasongo AA, Vijithakumar V, Abd-Elrahman KS, Prabhune R, Gharibeh L, Nadeau R, Robillard I, Spring S, Robichaud S, Asif S, Gibbings D, Moore KJ, Sled JG, Ruiz M, Lavallée-Adam M, Ferguson SSG, Lacoste B, Lagace DC, Ouimet M. Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production. J Lipid Res. 2025 Sep;66(9):100868. doi: 10.1016/j.jlr.2025.100868. Epub 2025 Jul 25. PMID: 40716750; PMCID: PMC12455110.
Breaking free from opioids: A turning point in acute pain management.
Abd-Elrahman KS, Peterson CD, Gross ER, Greenwood-Van Meerveld B. Breaking free from opioids: A turning point in acute pain management. J Pharmacol Exp Ther. 2025 Aug;392(8):103653. doi: 10.1016/j.jpet.2025.103653. Epub 2025 Jul 23. PMID: 40706135.
Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor.
Chen K, Park E, Abd-Elrahman KS. Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor. Mol Pharmacol. 2025 Apr;107(4):100027. doi: 10.1016/j.molpha.2025.100027. Epub 2025 Feb 28. PMID: 40158341; PMCID: PMC12060155.
Beyond weight loss: exploring the neurological ramifications of altered gut microbiota post-bariatric surgery.
Almheiri RT, Hajjar B, Alkhaaldi SMI, Rabeh N, Aljoudi S, Abd-Elrahman KS, Hamdan H. Beyond weight loss: exploring the neurological ramifications of altered gut microbiota post-bariatric surgery. J Transl Med. 2025 Feb 24;23(1):223. doi: 10.1186/s12967-025-06201-2. PMID: 39994634; PMCID: PMC11852891.
Unveiling the Interplay: Neurovascular Coupling, Astrocytes and G Protein-Coupled Receptors in Alzheimer’s Disease
Al-Jaf S, Soliman AY, El-Yazbi AF, Abd-Elrahman KS. Unveiling the Interplay: Neurovascular Coupling, Astrocytes and G Protein-Coupled Receptors in Alzheimer’s Disease. ACS Pharmacol Transl Sci. 2025 Jan 8;8(2):271-285. doi: 10.1021/acsptsci.4c00614. PMID: 39974631; PMCID: PMC11833731..
A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice
Abd-Elrahman KS, Colson TL, Sarasija S, Ferguson SSG. A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice. Biomed Pharmacother. 2024 Mar 8;173:116388. doi: 10.1016/j.biopha.2024.116388. Epub ahead of print. PMID: 38460371.
Sexual dimorphism of G protein-coupled receptor signaling in the brain
Aljoudi S, Hamdan H, Abd-Elrahman KS. Sexual dimorphism of G protein-coupled receptor signaling in the brain. Neural Regen Res. 2024 Aug 1;19(8):1635-1636. doi: 10.4103/1673-5374.389637. Epub 2023 Dec 11. PMID: 38103217; PMCID: PMC10960278
Targeting mGluR group III for the treatment of neurodegenerative diseases
Rabeh N, Hajjar B, Maraka JO, Sammanasunathan AF, Khan M, Alkhaaldi SMI, Mansour S, Almheiri RT, Hamdan H, Abd-Elrahman KS. Targeting mGluR group III for the treatment of neurodegenerative diseases. Biomed Pharmacother. 2023 Dec;168:115733. doi: 10.1016/j.biopha.2023.115733. Epub 2023 Oct 18. PMID: 37862967.
The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer’s Disease
Abd-Elrahman KS, Sarasija S, Ferguson SSG. The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer’s Disease. Curr Neuropharmacol. 2023;21(2):273-283. doi: 10.2174/1570159X19666210916102638. PMID: 34530715; PMCID: PMC10190143.
A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice
Abd-Elrahman, K. S., Sarasija, S., Colson, T.-L. L., & Ferguson, S. S. G. (2022). A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice. British Journal of Pharmacology, 179(8), 1769–1783. https://doi.org/10.1111/bph.15750
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer’s Disease
Abd-Elrahman KS, Ferguson SSG. Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer’s Disease. Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:235-254. doi: 10.1146/annurev-pharmtox-021821-091747. Epub 2021 Sep 13. PMID: 34516293.
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner
Khaled S. Abd-Elrahman et al. ,Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner.Sci. Signal.13,eabd2494(2020).DOI:10.1126/scisignal.abd2494
mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease
Abd-Elrahman KS, Hamilton A, Hutchinson SR, Liu F, Russell RC, Ferguson SSG. mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease. Sci Signal. 2017 Dec 19;10(510):eaan6387. doi: 10.1126/scisignal.aan6387. PMID: 29259100.
